In 1976, Alexander “Sasha” Shulgin, a brilliant and eccentric chemist who concocted hundreds of psychoactive drugs in a home-based laboratory in the hills of Berkeley, California, cooked up a batch of MDMA, the drug that later became known as Ecstasy or Molly. He then tried some, as was his habit.

He loved it. “I feel absolutely clean inside, and there is nothing but pure euphoria,” he wrote in his lab notes afterwards. “I have never felt so great, or believed this to be possible. The cleanliness, clarity, and marvelous feeling of solid inner strength continued throughout the rest of the day and evening. I am overcome by the profundity of the experience.”

This is quite the endorsement, if only because Shulgin took a lot of drugs during his long life.

Thirty five years later, MDMA is having a moment. A clinical trial of MDMA-assisted psychotherapy for PTSD, run by the Multidisciplinary Association for Psychedelic Studies, or MAPs, produced impressive results, moving the combination of MDMA and therapy closer to FDA approval. The first study of MDMA-assisted therapy for alcohol-use disorder, conducted by researchers at Imperial College in London and the University of Bristol, delivered encouraging, albeit very preliminary, findings. Researchers studying MDMA, as well as experienced users, say that the drug could be an effective way to treat other psychological ailments, while improving the health and happiness of so-called “healthy normals.”

You can read the rest of this story at Medium.

The philanthropy of the very rich is an exercise of power, says Stanford professor Rob Reich. As such, billionaire philanthropy deserves scrutiny and not automatic gratitude.

With that in mind, I began a deep dive three months ago into a campaign against electronic cigarettes funded largely by a $160-million, three-year grant from Bloomberg Philanthropies. Much of that went to the Campaign for Tobacco-Free Kids, the US's most powerful anti-tobacco nonprofit. Meantime, Michael Bloomberg, the patron of Bloomberg Philanthropies, billionaire founder of the Bloomberg media empire and former New York City mayor, spent millions of dollars of his own money fund political anti-vaping efforts, notably two ballot measures in San Francisco that led to ban on e-cigarettes in the city. A city where, not incidentally, you can still buy combustible cigarettes -- which are much more dangerous than e-cigs -- and marijuana. That makes no sense if what you care about is public health.

My research and reporting, which included 30 interviews, led to a story published today by The Chronicle of Philanthropy. The tobacco control movement is "neck-deep in intractable, internecine warfare" over vaping, Cliff Douglas, formerly of the American Cancer Society told me. Bloomberg, Tobacco-Free Kids and the major lung, cancer, and heart charities are on one side, opposing vaping, and pointing to its impact on kids and teens. Public health experts, by contrast, argue that e-cigarettes are a disruptive and potentially valuable technology that can and do help people quit smoking.

Little-known outside the world of psychedelics and drug policy, Rick Doblin is one of the most effective nonprofit leaders in America. Doblin is the founder and executive director of the Multidisciplinary Association for Psychedelic Studies, better known as MAPS, which for 35 years has been trying to develop psychedelic medicines and advocating for the responsible use of psychedelic drugs.

Doblin, in my view, is a brilliant strategist who has done more to change the narrative around psychedelics than anyone, with the possible exception of the writer Michael Pollan. He has built political alliances on the right and left, worked closely with medical researchers and, as best as I can tell, made few enemies along the way. MAPS is on the verge of a major breakthrough by securing FDA approval for the use of MDMA, along with talk therapy, as a prescription medicine to treat PTSD.

I tell the remarkable story of Doblin and MAPS at some length in the new issue of the Stanford Social Innovation Review. The story is ordinarily paywalled but it is available for free until April 1. Here's a link.

The act of coming out of the closet has been so important to the movement for gay rights that it is celebrated every year on National Coming Out Day. When people who are gay, lesbian, bisexual or transgender share their stories, they change hearts and minds, create new allies and help to dispel prejudices and misconceptions.

Can a similar dynamic help end the war on drugs?

Dr. Carl L. Hart, a professor of psychology at Columbia, and Charles Wininger, a Brooklyn-based psychoanalyst, are getting things rolling with new books. They chronicle their drug histories, describe the pleasures that drugs deliver and argue, persuasively, that the press and popular culture have left most Americans misinformed about the risks and benefits of illegal drugs.

You can read the rest of this story on Medium.

In my new story for @Medium, I try to figure out whether Richard Nixon called Timothy Leary "the most dangerous man in America." The quote has been published thousands of times. There's no evidence that Nixon ever said it. You can read the story here.

Alexandria Ocasio-Cortez is a progressive champion. Matt Gaetz is a conservative firebrand. They don’t agree on much — except psychedelics.

Ocasio-Cortez, a New York Democrat, and Gaetz, a Florida Republican, have joined forces in Congress to try to make it easier for scientists to research marijuana and psychedelic drugs, including MDMA and psilocybin.

Such bipartisan cooperation will be needed to support the growth of psychedelic medicines and end the drug war, says Jonathan Lubecky, a retired Army sergeant and Iraq war veteran who now lobbies on behalf of the Multidisciplinary Association for Psychedelic Studies, or MAPS.

“This isn’t a party line issue,” Lubecky says. “The polar opposites in the House came together on psychedelics.”

Voters are coming around as well. Last week, Oregon became the first state in the US to legalize a psychedelic medicine; about 56 percent of the state’s voters supported a ballot measure that will allow the medical use of psilocybin, the active ingredient in so-called magic mushrooms.

You can read the rest of this story here at Medium.

As medical director of the Aquilino Cancer Center, Dr. Manish Agrawal has seen the progress made possible by cancer research. Death rates from cancer have declined steadily among men and women.

But Dr. Agrawal has also seen patients struggle with depression and anxiety. Some cannot get the help they need.

“There’s so much emotional and psychological suffering that cancer patients and their families go through,” he says, “We never fully address that.”

Now, a small group of patients at Aquilino, an outpatient treatment center at Shady Grove Adventist Hospital in Rockville, MD, will have the chance to try something new — treatment that combines group therapy with a single dose of psilocybin, a psychedelic drug that is the active ingredient in so-called magic mushrooms. Psilocybin is illegal, but the government gives select researchers permission to use it in controlled clinical settings.

You can read the rest of this story on Medium

This should be a moment of opportunity for the animal rights movement. The case against eating animals — for ethical, environmental and health reasons — has never been stronger. Covid-19 may have begun at a live animal market in Wuhan and, so far, the virus has infected more than 41,000 workers at US meat and poultry slaughterhouses, according to the Food and Environmental Reporting Network,

All of that and more could have been fodder for this year’s Animal Rights National Conference, which was going to be held, virtually, in July.

Then it was cancelled — largely because of the behavior of Alex Hershaft, who started the event nearly four decades ago.

Hershaft, who is 86, is a survivor of the Warsaw Ghetto and a pioneer of the animal rights movement. He has a powerful personal story to tell. The Farm Animal Rights Movement (FARM), which he started in 1976, says it is the US’s first organization dedicated to protecting animals raised, abused and killed for food. When VegNews imagined a vegan Mount Rushmore, Hershaft’s face was carved into rock. This summer, Hershaft created his own Animal Rights Hall of Fame and installed himself as a member. Humble, he is not.

Unhappily, Hershaft failed to adapt to the times or listen to multiple warnings about his behavior. He ran FARM out of his home, repeatedly exposing staff members to pornography (and occasionally to his half-clothed torso). He has been hostile to feminists and supported men credibly accused of sexual harassment. He was slow to showcase women and people of color at the conference, and to respond to allegations of sexual harassment at the event.

You can read the rest of this story on Medium.

Pastor James Lindberg was unmoored by his first trip on psilocybin. “I’m a pretty normal middle aged white guy who found myself involved in things that were a bit larger than I intended them to be,” says Lindberg, who leads a Lutheran church in an Omaha suburb.

Rabbi Zac Kamenetz’s first journey on psilocybin led him to “light, connection, warmth, gratitude and the sense that all is well,” he says. “I left that experience inspired, energized and grounded, in the sense that the path that I was on was a noble one.” His next trip brought “darkness, emptiness and a void.”

Pastor Lindberg and Rabbi Kamenetz are participants in an FDA-approved study to examine the effects of psilocybin-facilitated experience on the psychology and effectiveness of religious professionals. The research aims to deepen understanding of what are called mystical, transcendental or awe-inspiring experiences.

The man helping to guide this mashup of science and the sacred — William A. “Bill” Richards, a researcher at the Johns Hopkins Center for Psychedelic & Consciousness Research — is uniquely qualified to do so. A clinical psychologist who has investigated psychedelics since the 1960s, Richards is an ordained minister (though he never pastored a church) with advanced degrees from Yale Divinity School and Andover-Newton Theological School. He has been guiding volunteers on drug trips on weekdays at Johns Hopkins and singing bass in the choir on Sundays at the Episcopal church where he worships in Baltimore.

You can read the rest of this story at Medium.

Civil rights. Feminism. Gay rights. Environmentalism. Meditation. Yoga. Natural childbirth.

Much of the politics and culture of the 1960s has been absorbed into mainstream America.

Not psychedelic drugs — not yet, anyway.

That will soon change if David Bronner, the CEO of family-owned soap-maker Dr. Bronner’s, has his way.

“Psychedelic medicine is the last and arguably the most powerful gift of the counter-culture that hasn’t been integrated,” says Bronner, who has put millions of dollars of his company’s money behind drug policy reform.

Bronner, 47, a pony-tailed vegan and an enthusiastic user of psychedelic drugs, says his life was transformed by a three-month sojourn in Amsterdam after college. He recently put $1 million of his family-owned company’s money behind a ground-breaking ballot initiative in Oregon.

You can read the rest of the story here on Medium.

Every October, Kingston, N.Y., a city of 23,000 people in the Hudson Valley, attracts throngs of visitors to the O + Festival, a weekend celebration of art, music and wellness.

The O + Festival — it’s pronounced O Positive — is no ordinary civic gathering. It is, improbably, an alternative to America’s profit-driven health care system: The artists and musicians who participate can barter their work for medical or dental care. Help paint a mural, get a cavity filled.

In a story about Kingston headlined The US city preparing itself for the collapse of capitalism, The Guardian last fall called O + Festival an “anti-capitalist, anti-establishment healthcare network” and an “example of a model that could supplant corporate America.” The story explains:

Locals have launched a non-commercial radio station, Radio Kingston WKNY, with widely representative, hyper-local programming that broadcasts via power generators if the grid goes dark. A regional micro-currency called the Hudson Valley Current now exists to, according to co-founder David McCarthy, “create an ecosystem that includes everyone.”

What the story neglects to say is that all these organizations — the O + festival, the radio station, the farm hub, the local currency project and Rise Up — share a powerful patron: The NoVo Foundation, led by Peter Buffet, the youngest son of legendary investor Warren Buffett, and Peter’s wife Jennifer. In 2010, Peter and Jennifer Buffett bought a 19th century farmhouse for $1.2 million in Kingston, a historic city perched on the west bank of the Hudson River, about 100 miles north of Manhattan.

“What started as a weekend getaway,” Buffett says, “became a core piece of what we’re doing at the foundation.”

You can read the rest of this story on Medium.

Philanthropic dollars helped to create today's psychedelic renaissance by funding medical research into the therapeutic benefits of psilocybin and LSD. The research has generated a great deal of excitement.

Now, startup companies want to bring psychedelic medicines to market. That's the topic of a story that I posted today at Medium.

Here's how it begins:

Despite Covid-19, a crashing economy and formidable legal obstacles, a growing number of entrepreneurs and investors are betting that medicines derived from psychedelic drugs can become a real business and heal millions of people. They are joining the researchers, activists, philanthropists and journalists who until now have been driving what’s been called the psychedelic renaissance.

A dozen or more startup companies are developing medicines from psilocybin, MDMA, ibogaine and LSD, all of which are illegal in the US, as well as from ketamine, a legal anesthetic with hallucinogenic properties. They hope to treat a surprisingly wide range of mental conditions, including post-traumatic stress disorder (PTSD), depression, anxiety, addiction, even Alzheimer’s disease.

This is excellent news. Developing new drugs is an expensive proposition. Especially in today's tough environment for fundraising, nonprofits are likely to have a hard time bringing in enough donations to stage clinical trials, secure regulatory approval, manufacture and distribute the medicines, persuade doctors to use them and convince insurance companies to pay for them.

Investors, by contrast, may be willing to risk their money with the hope of eventually making a financial return.

You can read the full story here on Medium.

When writing about foundations and nonprofits, I try to keep something in mind: Surprisingly few social programs are effective. When subjected to rigorous evaluation, most fail to produce "meaningful progress in education, poverty reduction, crime prevention and other areas," as Arnold Ventures puts it. This is one reason why my favorite charity remains GiveDirectly, which sends money to those living in extreme poverty, mostly in Africa.

Cash, at the very least, makes people a little less poor.

Few foundations, though, have funded direct cash transfers--until now. So I was heartened to learn last week that some big, influential funders are supporting programs to give away money, with no strings attached, to Americans suffering from the economic impacts of the COVID-19 pandemic.

I wrote about this for Medium. Here's how my story begins:

The well-educated folk who lead America’s big foundations have over the years devised no end of theories about how to do what they do. Strategic philanthropy. Collective impact. Venture philanthropy. Big bets. Participatory grantmaking. Trust-based philanthropy.

Now, in response to the economic devastation caused by COVID-19, they are trying something completely different: Giving money, with no strings attached, to those who need it.

Foundations that are supporting direct cash transfers include Blue Meridian Partners (a funding collaborative) and the Robert Wood Johnson Foundation, as well as the foundations of Charles Koch, Pierre Omidyar, Steve Ballmer and Sergey Brin.

You can read the rest of my story here.

This is a remarkable moment for psychedelics. Elite universities, including Johns Hopkins and Imperial College in London, have opened centers to research the medical benefits of such drugs as psilocybin, a hallucinogen found in mushrooms. The nonprofit Multidisciplinary Association for Psychedelic Research (MAPS) is recruiting people suffering from PTSD to participate in FDA-approved clinical trials using MDMA, better known as molly or ecstasy. CBS News’ 60 Minutes last fall reported on life-changing psychedelic journeys.

So far, the psychedelic renaissance has focused on the potential of these dugs to heal mental illness, and rightly so. A growing body of research suggests that they can alleviate suffering caused by a broad array of ailments: depression, addiction and anxiety, among others.

This story, though, is not about how psychedelics can heal the mind. It’s about how they can heal the world. There is sickness all around us. The threat of climate change. Unconscionable poverty amidst great wealth. Extreme political polarization. These are manifestations of deeper ills: People feel disconnected from one another and from nature.

Serious people — not just hippies, but neuroscientists with PhDs, and their philanthropic supporters — say psychedelics can help address these deeper problems. Drug trips, under controlled conditions, break down the barriers between people and bring users closer to nature.

“These medicines can help us wake up to new levels of caring and concern,” says David Bronner, a philanthropist and the CEO of Dr. Bronner’s, the family-owned maker of natural soaps. “It’s crucial to wake up to the miraculous world we’re part of and understand how we can serve and make it better for all of us.”

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You can read the rest of the story on Medium.

My wife Karen Schneider and I gave away about nine percent of our pretax income in 2019. Like most people, I delayed my charitable giving until the end of the year--a bad practice, because nonprofits have needs all year--so I’m just now writing my annual blogpost about where the money went. The Life You Can Save, a nonprofit inspired by the moral philosopher Peter Singer, has a calculator that recommends the percentage of your income that you should give, as well as an excellent list of top charities.*

My biggest gift went to GiveDirectly, which makes unconditional cash grants to people living in extreme poverty. Give Directly is my favorite charity. In 2018, I traveled to Rwanda to see how the organization operates and talk to recipients of its grants. I could say a lot about GiveDirectly but my biggest takeaway from the trip was this: The money that well-to-do Americans spend on a few restaurant meals, or for a single night in a nice hotel, is enough to make a meaningful difference to the life of a poor person in Africa. If you care about inequality--and it seems that more and more people do--there’s no better charity than GiveDirectly.

Next on the list is GiveWell, a donation platform that identifies and analyzes effective charities in depth. If you want to do the most good you can for each dollar that you spend on charity, GiveWell is essential. Most of the money it raises flows to charity that improve global health, in particular by helping poor people protect themselves against malaria.